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Article

Sirolimus population pharmacokinetic/pharmacogenetic analysis and bayesian modelling in kidney transplant recipients.

Clinical pharmacokinetics - 1 Jan 2006

Djebli Nassim, Rousseau Annick, Hoizey Guillaume, Rerolle Jean-Philippe, Toupance Olivier, Le Meur Yann, Marquet Pierre

Abstract excerpt

OBJECTIVES: The objectives of the present study were: (i) to analyse the population pharmacokinetics of sirolimus in renal transplant recipients co-administered mycophenolate mofetil, but no calcineurin inhibitor over the first 3 months post-transplantation and study the influence of different potential covariates, including genetic polymorphisms of cytochrome P450 (CYP) metabolic enzymes and active transporters,...

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Identifiers

PMID: 17048977
DOI: 10.2165/00003088-200645110-00007

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