Article

Comprehensive profiling of the mutational landscape of hidradenoma papilliferum validates key role of alterations in the PI3K/AKT pathway alterations

2025-04-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Hidradenoma papilliferum (HP) is a rare, benign epithelial tumour arising from the anogenital mammary-like glands, that occurs almost exclusively in the anogenital region of middle-aged women. To-date, genetic characterisation of HP has identified recurrent somatic mutations in PIK3CA and AKT1, which appear to be mutually exclusive, and PIK3R1 mutations in some cases without P...

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Literature Corpus work: 8defff35-d94c-54d5-acb7-55c3d9aa6e13
DOI: 10.1101/2025.03.31.25324887

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