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Article

Frequent PIK3CA-activating mutations in hidradenoma papilliferums.

Human pathology - 1 Sept 2016

Liau Jau-Yu, Lan Jui, Hong Jin-Bon, Tsai Jia-Huei, Kuo Kuan-Tin, Chu Chia-Yu, Sheen Yi-Shuan, Huang Wen-Chang

Abstract excerpt

Hidradenoma papilliferum (HP) is a benign epithelial tumor most commonly seen in the vulva. It is proposed to be derived from the anogenital mammary-like glands and is histologically very similar to the mammary intraductal papilloma (IP). Approximately 60% of mammary IPs have activating mutations in either PIK3CA or AKT1, with each gene accounting for 30% of cases. In this study, we screened the mutation statuses...

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Source

Identifiers

PMID: 27184479
DOI: 10.1016/j.humpath.2016.04.014

Genes

AKT1
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Frequent PIK3CA-activating mutations in hidradenoma papilliferums.PMID 27184479Read ↗

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Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor.Semantic proximity Read ↗

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