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Article

Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K-AKT pathway.

Genes, chromosomes & cancer - 1 Jan 2017

Volckmar Anna-Lena, Leichsenring Jonas, Flechtenmacher Christa, Pfarr Nicole, Siebolts Udo, Kirchner Martina, Budczies Jan, Bockmayr Michael, Ridinger Kathrin, Lorenz Katja, Herpel Esther, Noske Aurelia, Weichert Wilko, Klauschen Frederick, Schirmacher Peter, Penzel Roland, Endris Volker, Stenzinger Albrecht

Abstract excerpt

Adenomas of the breast are rare benign tumors although single cases with malignant behavior have been reported. However, the genetic basis of these tumors is unknown. Employing targeted next generation sequencing of 50 cancer-related genes as well as Sanger sequencing, we profiled a cohort of 18 mammary adenomas comprising 9 ductal, 6 tubular, and 3 lactating adenoma. Missense mutations were detected in 8 of the...

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Identifiers

PMID: 27438523
DOI: 10.1002/gcc.22396

Genes

GNAS
MED12
AKT1
FGFR3
MET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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