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Article

Mutations in genes encoding PI3K-AKT and MAPK signaling define anogenital papillary hidradenoma.

Genes, chromosomes & cancer - 1 Feb 2016

Pfarr Nicole, Sinn Hans-Peter, Klauschen Frederick, Flechtenmacher Christa, Bockmayr Michael, Ridinger Kathrin, von Winterfeld Moritz, Warth Arne, Lorenz Katja, Budczies Jan, Penzel Roland, Lennerz Jochen K, Endris Volker, Weichert Wilko, Stenzinger Albrecht

Abstract excerpt

Papillary hidradenoma (a.k.a. hidradenoma papilliferum) is a benign tumor of the anogenital region that almost exclusively arises in middle-aged Caucasian women. These tumors may recur and rare cases of malignant development have been reported. The genetic basis of papillary hidradenoma is currently unknown. Hence, we employed targeted high-coverage next generation sequencing interrogating 50 cancer-related genes...

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Source

Identifiers

PMID: 26493284
DOI: 10.1002/gcc.22315

Genes

BRAF
AKT1
APC
ERBB4
STK11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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