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Article

Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.

Experimental gerontology - 1 Sept 2007

Cheng Wen-Hsing, Muftuoglu Meltem, Bohr Vilhelm A

Abstract excerpt

Werner syndrome (WS) is an excellent model system for the study of human aging. WRN, a nuclear protein mutated in WS, plays multiple roles in DNA metabolism. Our understanding about the metabolic regulation and function of this RecQ helicase has advanced greatly during the past decade, largely due to the availability of purified WRN protein, WRN knockdown cells, and WRN knockout mice. Recent biochemical and...

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Source

Identifiers

PMID: 17587522
DOI: 10.1016/j.exger.2007.04.011

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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