Article
Clinical features of interleukin 10 receptor gene mutations in children with very early-onset inflammatory bowel disease.
Journal of pediatric gastroenterology and nutrition - 1 Mar 2015
Beser Omer F, Conde Cecilia Dominguez, Serwas Nina K, Cokugras Fügen Cullu, Kutlu Tufan, Boztug Kaan, Erkan Tulay
Abstract excerpt
OBJECTIVES: In the present study, we studied a cohort of patients with very early onset inflammatory bowel disease (IBD) to determine the frequency of mutations in the interleukin 10 (IL10) receptor genes as a cause of early-onset IBD. METHODS: Sanger sequencing was performed to determine the presence of IL10 and/or IL10 receptor mutations in 17 patients with a diagnosis of very early onset IBD (disease onset <2...
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