Article
Clinical outcome in IL-10- and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation.
The Journal of allergy and clinical immunology - 1 Mar 2013
Engelhardt Karin R, Shah Neil, Faizura-Yeop Intan, Kocacik Uygun Dilara F, Frede Natalie, Muise Aleixo M, Shteyer Eyal, Filiz Serkan, Chee Ronnie, Elawad Mamoun, Hartmann Britta, Arkwright Peter D, Dvorak Christopher, Klein Christoph, Puck Jennifer M, Grimbacher Bodo, Glocker Erik-Oliver
Abstract excerpt
BACKGROUND: Inherited deficiencies of IL-10 or IL-10 receptor (IL-10R) lead to immune dysregulation with life-threatening early-onset enterocolitis. OBJECTIVES: We sought to gather clinical data of IL-10/IL-10R-deficient patients and devise guidelines for diagnosis and management, including hematopoietic stem cell transplantation (HSCT). METHODS: We enrolled 40 patients with early-onset enterocolitis and screened...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.