Article
CD40 signalling induces IL-10-producing, tolerogenic dendritic cells.
Experimental dermatology - 1 Jan 2010
Tuettenberg Andrea, Fondel Sabine, Steinbrink Kerstin, Enk Alexander H, Jonuleit Helmut
Abstract excerpt
Dendritic cells (DC) are potent antigen-presenting cells capable to induce efficient antigen-specific T cell responses in vitro and in vivo. Herein, the maturation process is of great significance, as immature DC (iDC) are known to induce rather regulatory than effector T cell differentiation. This study was designed to characterize the role of the CD40-CD40L pathway for differentiation and function of human DC....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.