Article
CD40 engagement strongly induces CD25 expression on porcine dendritic cells and polarizes the T cell immune response toward Th1.
Molecular immunology - 1 Jan 2009
Pilon Caroline, Levast Benoit, Meurens François, Le Vern Yves, Kerboeuf Dominique, Salmon Henry, Velge-Roussel Florence, Lebranchu Yvon, Baron Christophe
Abstract excerpt
Orientation of the immune response toward Th1, Th2, Th17 or Treg plays an important role in self-tolerance and defence against pathogens and tumors. However, this orientation has not been fully characterised in the pig and little is known about the influence of maturation stimulus on the capacity of dendritic cells selectively to direct different types of Th cell responses. Dendritic cell (DC) maturation can be...
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