Article
IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction--a comparative study of human clinical-applicable DC.
Clinical immunology (Orlando, Fla.) - 1 Mar 2012
Boks Martine A, Kager-Groenland Judith R, Haasjes Michiel S P, Zwaginga Jaap Jan, van Ham S Marieke, ten Brinke Anja
Abstract excerpt
Tolerogenic dendritic cells (tDC) are a promising tool for specific cellular therapy to induce immunological tolerance in transplantation and autoimmunity. To date, most described tDC methods have not been converted into clinically applicable protocols and systematic comparison of required functional characteristics, i.e. migration and functional regulatory T cell (Treg) induction, is lacking. We compare...
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