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Article

Activation of immature monocyte-derived dendritic cells after transduction with high doses of lentiviral vectors.

Human gene therapy - 1 Jun 2007

Breckpot Karine, Emeagi Perpetua, Dullaers Melissa, Michiels Annelies, Heirman Carlo, Thielemans Kris

Abstract excerpt

Dendritic cells (DCs) are an attractive tool for immunomodulation, targeting mature DCs (mDCs) for immunization or immature/semimature DCs (iDCs) for tolerization. Therefore, introducing antigens into DCs has become a prime topic in various immunological disciplines. Numerous studies have shown that lentiviruses are an efficient vehicle for this purpose. This study evaluates the effects of lentiviral transduction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17576158
DOI: 10.1089/hum.2007.006

Genes

TLR2
TLR3
TLR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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