Article
CD40ligand-expressing dendritic cells induce regression of hepatocellular carcinoma by activating innate and acquired immunity in vivo.
Hepatology (Baltimore, Md.) - 1 Jul 2008
Gonzalez-Carmona Maria A, Lukacs-Kornek Veronika, Timmerman Anne, Shabani Sara, Kornek Miroslaw, Vogt Annabelle, Yildiz Yildiz, Sievers Elisabeth, Schmidt-Wolf Ingo G H, Caselmann Wolfgang H, Sauerbruch Tilman, Schmitz Volker
Abstract excerpt
UNLABELLED: Dendritic cells (DCs) are professional antigen-presenting cells able to prime T-cells against tumor-associated antigens (TAA), but their potential to induce hepatocellular carcinoma (HCC) regression is still limited. CD40/CD40L interaction is essential for DC activation and induction of antigen-specific T-cells. In this study, transduction of TAA-pulsed DC with a CD40L-encoding adenovirus (Ad-CD40L)...
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