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Article

Circulating tumor DNA outperforms circulating tumor cells for KRAS mutation detection in thoracic malignancies.

Clinical chemistry - 1 Oct 2015

Freidin Maxim B, Freydina Dasha V, Leung Maria, Montero Fernandez Angeles, Nicholson Andrew G, Lim Eric

Abstract excerpt

BACKGROUND: Circulating biomarkers, such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), are both considered for blood-based mutation detection, but limited studies have compared them in a head-to-head manner. Using KRAS (Kirsten rat sarcoma viral oncogene homolog), we performed such a comparison in patients who underwent surgery for suspected lung cancer. METHODS: We recruited 93 patients,...

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Share to DNA, Neoplasm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplastic Cells, Circulating

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Share to Proto-Oncogene Proteins p21(ras)

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Source

Identifiers

PMID: 26272233
DOI: 10.1373/clinchem.2015.242453

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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