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Article

KRAS genotyping of paraffin-embedded colorectal cancer tissue in routine diagnostics: comparison of methods and impact of histology.

The Journal of molecular diagnostics : JMD - 1 Jan 2010

Weichert Wilko, Schewe Christiane, Lehmann Annika, Sers Christine, Denkert Carsten, Budczies Jan, Stenzinger Albrecht, Joos Hans, Landt Olfert, Heiser Volker, Röcken Christoph, Dietel Manfred

Abstract excerpt

KRAS mutation testing before anti-epidermal growth factor receptor therapy of metastatic colorectal cancer has become mandatory in Europe. However, considerable uncertainty exists as to which methods for detection can be applied in a reproducible and economically sound manner in the routine diagnostic setting. To answer this question, we examined 263 consecutive routine paraffin slide specimens. Genomic DNA was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20007841
DOI: 10.2353/jmoldx.2010.090079
PMCID: PMC2797716

Genes

KRAS

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