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Article

Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon.

Cellular and molecular life sciences : CMLS - 24 Dec 2021

Stenvall Carl-Gustaf A, Tayyab Mina, Grönroos Tove J, Ilomäki Maria A, Viiri Keijo, Ridge Karen M, Polari Lauri, Toivola Diana M

Abstract excerpt

Keratin 8 (K8) is the main intestinal epithelial intermediate filament protein with proposed roles for colonic epithelial cell integrity. Here, we used mice lacking K8 in intestinal epithelial cells (floxed K8 and Villin-Cre1000 and Villin-CreERt2) to investigate the cell-specific roles of intestinal epithelial K8 for colonocyte function and pathologies. Intestinal epithelial K8 deletion decreased K8 partner...

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Identifiers

PMID: 34951664
DOI: 10.1007/s00018-021-04081-5
PMCID: PMC8709826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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