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Integrin-linked kinase (ILK): the known vs. the unknown and perspectives

28 Jan 2022

Abstract excerpt

Integrin-linked kinase (ILK) is a multifunctional molecular actor in cell-matrix interactions, cell adhesion, and anchorage-dependent cell growth. It combines functions of a signal transductor and a scaffold protein through its interaction with integrins, then facilitating further protein recruitment within the ILK-PINCH-Parvin complex. ILK is involved in crucial cellular processes including proliferation,...

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PMID: 35089438
DOI: 10.1007/s00018-021-04104-1

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