Expression of ILK in renal stroma is essential for multiple aspects of renal development.

doi:10.1152/ajprenal.00509.2017

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Article

Expression of ILK in renal stroma is essential for multiple aspects of renal development.

American journal of physiology. Renal physiology - 1 Aug 2018

Gong Xiaohui, Guo Xiaoxia, Huang Ru, Liao Huimin, Zhang Qingquan, Yan Jie, Luo Lina, Zhang Qitong, Qiu Andong, Sun Yunfu, Liang Xingqun

Abstract excerpt

Kidney development involves reciprocal and inductive interactions between the ureteric bud (UB) and surrounding metanephric mesenchyme. Signals from renal stromal lineages are essential for differentiation and patterning of renal epithelial and mesenchymal cell types and renal vasculogenesis; however, underlying mechanisms remain not fully understood. Integrin-linked kinase (ILK), a key component of integrin...

Topics

Animals
Bone Morphogenetic Protein 7
Cell Differentiation
Cell Lineage
Gene Expression Regulation, Developmental
Genetic Predisposition to Disease
Gestational Age
Glial Cell Line-Derived Neurotrophic Factor
Integrases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kidney

Mice, Knockout

Mitogen-Activated Protein Kinases

Morphogenesis

Phenotype

Phosphatidylinositol 3-Kinase

Polycystic Kidney Diseases

Protein Serine-Threonine Kinases

Proto-Oncogene Proteins c-akt

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Open in PubMed

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PMID: 29638158
DOI: 10.1152/ajprenal.00509.2017

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