The Integrin-Mediated ILK-Parvin-αPix Signaling Axis Controls Differentiation in Mammary Epithelial Cells.

doi:10.1002/jcp.25390

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Article

The Integrin-Mediated ILK-Parvin-αPix Signaling Axis Controls Differentiation in Mammary Epithelial Cells.

Journal of cellular physiology - 1 Nov 2016

Rooney Nicholas, Wang Pengbo, Brennan Keith, Gilmore Andrew P, Streuli Charles H

Abstract excerpt

Epithelial cell adhesion to the surrounding extracellular matrix is necessary for their proper behavior and function. During pregnancy and lactation, mammary epithelial cells (MECs) receive signals from their interaction with laminin via β1-integrin (β1-itg) to establish apico-basal polarity and to differentiate in response to prolactin. Downstream of β1-itg, the scaffold protein Integrin Linked Kinase (ILK) has...

Topics

Animals
Cell Differentiation
Cell Polarity
Cell Proliferation
Epithelial Cells
Female
Gene Knockdown Techniques
Integrin beta1
Mammary Glands, Animal
Mice
Microfilament Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Prolactin

Protein Binding

Protein Serine-Threonine Kinases

Rho Guanine Nucleotide Exchange Factors

Signal Transduction

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PMID: 27019299
DOI: 10.1002/jcp.25390
PMCID: PMC5053222

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