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Article

A novel role for integrin-linked kinase in epithelial sheet morphogenesis.

Molecular biology of the cell - 1 Sept 2005

Vespa Alisa, D'Souza Sudhir J A, Dagnino Lina

Abstract excerpt

Integrin-linked kinase (ILK) is a multidomain protein involved in cell motility and cell-extracellular matrix interactions. ILK is found in integrin-containing focal adhesions in undifferentiated primary epidermal keratinocytes. Induction of keratinocyte differentiation by treatment with Ca(2+) triggers formation of cell-cell junctions, loss of focal adhesions, and ILK distribution to cell borders. We now show...

Topics

Adherens Junctions
Animals
Ankyrin Repeat
Cell Differentiation
Cells, Cultured
Epithelium
Fluorescent Antibody Technique, Indirect
Keratinocytes
Kinetics
Mice
Mutation
Protein Serine-Threonine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Transport

Tight Junctions

Source

Open in PubMed Open full text

Identifiers

PMID: 15975904
DOI: 10.1091/mbc.e05-02-0087
PMCID: PMC1196321

Genes

ILK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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