ILK over‐expression in human colon cancer progression correlates with activation of β‐catenin, down‐regulation of E‐cadherin and activation of the Akt–FKHR pathway

Abstract excerpt

Integrin-linked kinase (ILK) has been implicated in the development and progression of several human malignancies. However, the role of ILK in human colon cancer progression is not well established, neither have its possible in vivo downstream effectors in the disease been identified. We studied, by immunohistochemistry, ILK, beta-catenin, E-cadherin, p-Akt and p-FKHR protein expression in 125 primary colon...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Adhesion Molecules Research
• Share to Galectins and Cancer Biology
• Share to Signaling Pathways in Disease