Article
Parental history of Alzheimer disease associated with lower plasma apolipoprotein E levels.
Neurology - 1 Sept 2009
van Vliet P, Westendorp R G J, Eikelenboom P, Comijs H C, Frölich M, Bakker E, van der Flier W, van Exel E
Abstract excerpt
BACKGROUND: Variation in APOE genotype is a determinant of Alzheimer disease (AD), but the risk associated with variation in plasma apoE levels has yet to be determined. Here, we studied offspring with and without a parental history of AD to identify the effect of plasma apoE levels at middle age on the risk of late-onset AD. METHODS: Some 203 offspring from 92 families with a parental history of AD were compared...
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