Article
Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study.
Neurobiology of aging - 1 Feb 2021
Low Audrey, Su Li, Stefaniak James D, Mak Elijah, Dounavi Maria-Eleni, Muniz-Terrera Graciela, Ritchie Karen, Ritchie Craig W, Markus Hugh S, O'Brien John T
Abstract excerpt
Cerebral small vessel disease (SVD) and inflammation are increasingly recognized as key contributors to Alzheimer's disease (AD), although the timing, trajectory, and relation between them early in the disease process is unclear. Therefore, to investigate very early-stage changes, we compared 158 healthy midlife adults with and without inherited AD predisposition (APOE4 carriership (38% positive), parental family...
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