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Article

Overexpression of the dominant-negative form of myostatin results in doubling of muscle-fiber number in transgenic medaka (Oryzias latipes).

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology - 1 Feb 2010

Sawatari Etsuko, Seki Ryoko, Adachi Tomoko, Hashimoto Hisashi, Uji Susumu, Wakamatsu Yuko, Nakata Takahiro, Kinoshita Masato

Abstract excerpt

In addition to altering the phenotypes of gene-modified animals, transgenesis also has the potential to facilitate access to the various mechanisms underlying the development and functioning of specific phenotypes and genes, respectively. Myostatin (MSTN) is implicated in double-muscling when mutated in mammals, indicating that MSTN is a negative regulator of skeletal muscle formation. In order to elucidate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19883781
DOI: 10.1016/j.cbpa.2009.10.030

Genes

MSTN

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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