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Mutations in the myostatin gene leading to hypermuscularity in mammals: indications for a similar mechanism in fish?

Animal genetics - 1 Jun 2011

Stinckens A, Georges M, Buys N

Abstract excerpt

The transforming growth factor β (TGF-β) superfamily encodes secreted factors that are important in regulating embryonic development and tissue homeostatis in adults. Myostatin (MSTN, encoded by MSTN) or 'growth and differentiation factor 8', a member of this superfamily, is a negative regulator of skeletal muscle growth and is highly conserved among animal species. In 1997, a mutation associated with the...

Topics

Animals
Fishes
Humans
Mammals
Muscle Development
Muscle, Skeletal
Mutation
Myostatin

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21175702
DOI: 10.1111/j.1365-2052.2010.02144.x

Genes

MSTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Mutations in the myostatin gene leading to hypermuscularity in mammals: indications for a similar mechanism in fish?PMID 21175702Read ↗

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