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Article

TALENs-mediated gene disruption of myostatin produces a larger phenotype of medaka with an apparently compromised immune system.

Fish & shellfish immunology - 1 Jan 2016

Chiang Yi-An, Kinoshita Masato, Maekawa Shun, Kulkarni Amod, Lo Chu-Fang, Yoshiura Yasutoshi, Wang Han-Ching, Aoki Takashi

Abstract excerpt

Although myostatin, a suppressor of skeletal muscle development and growth, has been well studied in mammals, its function in fish remains unclear. In this study, we used a popular genome editing tool with high efficiency and target specificity (TALENs; transcription activator-like effector nucleases) to mutate the genome sequence of myostatin (MSTN) in medaka (Oryzias latipes). After the TALEN pair targeting...

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PMID: 26578247
DOI: 10.1016/j.fsi.2015.11.016

Genes

MSTN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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