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Article

Expression of myostatin pro domain results in muscular transgenic mice.

Molecular reproduction and development - 1 Nov 2001

Yang J, Ratovitski T, Brady J P, Solomon M B, Wells K D, Wall R J

Abstract excerpt

Myostatin, a member of the TGF-beta family, negatively regulates skeletal muscle development. Depression of myostatin activity leads to increased muscle growth and carcass lean yield. In an attempt to down-regulate myostatin, transgenic mice were produced with a ribozyme-based construct or a myostatin pro domain construct. Though the expression of the ribozyme was detected, muscle development was not altered by...

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PMID: 11599046
DOI: 10.1002/mrd.1097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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