Article
Expression of myostatin pro domain results in muscular transgenic mice.
Molecular reproduction and development - 1 Nov 2001
Yang J, Ratovitski T, Brady J P, Solomon M B, Wells K D, Wall R J
Abstract excerpt
Myostatin, a member of the TGF-beta family, negatively regulates skeletal muscle development. Depression of myostatin activity leads to increased muscle growth and carcass lean yield. In an attempt to down-regulate myostatin, transgenic mice were produced with a ribozyme-based construct or a myostatin pro domain construct. Though the expression of the ribozyme was detected, muscle development was not altered by...
Topics
- Adipose Tissue
- Animals
- Body Weight
- Female
- Gene Expression
- Hypertrophy
- Male
- Mice
- Mice, Knockout
- Mice, Transgenic
- Muscle, Skeletal
- Myocardium
- Myosin Light Chains
- Myostatin
- Phenotype
- Protein Structure, Tertiary
- RNA, Catalytic
- Rats