Article
Myostatin gene silenced by RNAi show a zebrafish giant phenotype.
Journal of biotechnology - 10 Oct 2005
Acosta Jannel, Carpio Yamila, Borroto Ingrid, González Osmany, Estrada Mario Pablo
Abstract excerpt
Myostatin is a member of the transforming growth factor-beta (TGF-beta) family that functions as a negative regulator of skeletal muscle development and growth. Recently, it has been reported that the transgenic zebrafish expressing myostatin prodomain exhibited an increased number of fiber in skeletal muscle. Other novel results suggest that myostatin plays a mayor role during myogenesis, apart from inhibition...
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