Article
Using CRISPR/Cas9-mediated gene editing to further explore growth and trade-off effects in myostatin-mutated F4 medaka (Oryzias latipes).
Scientific reports - 12 Sept 2017
Yeh Ying-Chun, Kinoshita Masato, Ng Tze Hann, Chang Yu-Hsuan, Maekawa Shun, Chiang Yi-An, Aoki Takashi, Wang Han-Ching
Abstract excerpt
Myostatin (MSTN) suppresses skeletal muscle development and growth in mammals, but its role in fish is less well understood. Here we used CRISPR/Cas9 to mutate the MSTN gene in medaka (Oryzias latipes) and evaluate subsequent growth performance. We produced mutant F0 fish that carried different frameshifts in the OlMSTN coding sequence and confirmed the heritability of the mutant genotypes to the F1 generation....
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