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Article

HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancer.

Clinical epigenetics - 11 Jan 2022

Pantelaiou-Prokaki Garyfallia, Mieczkowska Iga, Schmidt Geske E, Fritzsche Sonja, Prokakis Evangelos, Gallwas Julia, Wegwitz Florian

Abstract excerpt

BACKGROUND: Basal-like breast cancer (BLBC) is one of the most aggressive malignant diseases in women with an increased metastatic behavior and poor prognosis compared to other molecular subtypes of breast cancer. Resistance to chemotherapy is the main cause of treatment failure in BLBC. Therefore, novel therapeutic strategies counteracting the gain of aggressiveness underlying therapy resistance are urgently...

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Identifiers

PMID: 35016723
DOI: 10.1186/s13148-022-01228-4
PMCID: PMC8753869

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