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Article

Emerging roles of BRCA1 in transcriptional regulation and DNA repair.

Journal of cellular physiology - 1 Dec 1999

Chen Y, Lee W H, Chew H K

Abstract excerpt

BRCA1 was the first breast cancer susceptibility gene to be identified and cloned. In individuals from high-risk families, mutations in BRCA1 increase the lifetime risk of developing breast cancer eight to tenfold, compared to the general population. How the BRCA1 protein product normally functions to suppress tumor formation and how defects in the gene can ultimately lead to breast cancer have been the focus of...

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Source

Identifiers

PMID: 10528224
DOI: 10.1002/(SICI)1097-4652(199912)181:3<385::AID-JCP2>3.0.CO;2-4

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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