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Article

Depletion of human histone H1 variants uncovers specific roles in gene expression and cell growth.

PLoS genetics - 1 Oct 2008

Sancho Mónica, Diani Erika, Beato Miguel, Jordan Albert

Abstract excerpt

At least six histone H1 variants exist in somatic mammalian cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be actively involved in the regulation of gene expression. However, it is not well known whether the different variants have distinct roles or if they regulate specific promoters. We have explored this by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18927631
DOI: 10.1371/journal.pgen.1000227
PMCID: PMC2563032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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