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Interferon-γ signaling is associated with BRCA1 loss-of-function mutations in high grade serous ovarian cancer

6 Dec 2019

Abstract excerpt

Abstract Loss-of-function mutations of the breast cancer type 1 susceptibility protein (BRCA1) are associated with breast (BC) and ovarian cancer (OC). To identify gene signatures regulated by epigenetic mechanisms in OC cells carrying BRCA1 mutations, we assessed cellular responses to epigenome modifiers and performed genome-wide RNA- and chromatin immunoprecipitation-sequencing in isogenic OC cells UWB1.289...

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PMID: 31840082
DOI: 10.1038/s41698-019-0103-4

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