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Article

BRCA1 transcriptionally regulates genes involved in breast tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America - 28 May 2002

Welcsh Piri L, Lee Ming K, Gonzalez-Hernandez Rachel M, Black Daniel J, Mahadevappa Mamatha, Swisher Elizabeth M, Warrington Janet A, King Mary-Claire

Abstract excerpt

Loss of function of BRCA1 caused by inherited mutation and tissue-specific somatic mutation leads to breast and ovarian cancer. Nearly all BRCA1 germ-line mutations involve truncation or loss of the C-terminal BRCT transcriptional activation domain, suggesting that transcriptional regulation is a critical function of the wild-type gene. The purpose of this project was to determine whether there is a link between...

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Share to Genes, BRCA1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 12032322
DOI: 10.1073/pnas.062181799
PMCID: PMC124283

Genes

BRCA1
JAK1
MYC
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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