Article
BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers.
Oncogene - 9 Aug 2012
Tkocz D, Crawford N T, Buckley N E, Berry F B, Kennedy R D, Gorski J J, Harkin D P, Mullan P B
Abstract excerpt
In this study we describe a novel interaction between the breast/ovarian tumor suppressor gene BRCA1 and the transcription factor GATA3, an interaction, which is important for normal breast differentiation. We show that the BRCA1-GATA3 interaction is important for the repression of genes associated with triple-negative and basal-like breast cancer (BLBCs) including FOXC1, and that GATA3 interacts with a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.