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Article

Tales from the crypt.

The Journal of clinical investigation - 1 Nov 2003

Schon Eric A

Abstract excerpt

Intestinal colonic crypts are derived from a stem cell population located at the base of each crypt. A new analysis of mitochondrial function and of the rates of mitochondrial DNA (mtDNA) mutation in individual crypts shows that mtDNA mutations arise in stem cells - and at a surprisingly high frequency. Because crypts turn over extremely rapidly (about once per week), somatic mtDNA mutations can "take over the...

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Identifiers

PMID: 14597757
DOI: 10.1172/JCI20249
PMCID: PMC233116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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