Article
Mitochondrial DNA Mutations in Colorectal Cancer Stem Cells: Implications for Tumor Dynamics and Therapeutic Strategies.
Current medicinal chemistry - 1 Jan 2026
Shakhpazyan Nikolay K, Mikhaleva Liudmila M, Bedzhanyan Arkady L, Gioeva Zarina, Mikhalev Alexander, Midiber Konstantin Y, Konyukova Alexandra K, Atiakshin Dmitrii, Buchwalow Igor, Tiemann Markus, Orekhov Alexander N
Abstract excerpt
This review offers an in-depth analysis of mitochondrial DNA (mtDNA) mutations in colorectal cancer stem cells (CSCs), emphasizing their significant impact on tumor dynamics and potential therapeutic strategies. CSCs are a special subpopulation due to their unique capabilities for self-renewal, differentiation, and resistance to conventional therapies. Given that CSCs significantly differ from other tumor cell...
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