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Article

Differences in the accumulation of mitochondrial defects with age in mice and humans.

Mechanisms of ageing and development - 1 Jan 2000

Greaves Laura C, Barron Martin J, Campbell-Shiel George, Kirkwood Thomas B L, Turnbull Douglass M

Abstract excerpt

Mitochondrial DNA mutations and associated defects in cytochrome c oxidase (COX) are proposed to play an important role in human ageing; however there have been limited studies on the frequency of these defects in normal mouse ageing. Here we compare COX-deficiency in two epithelial tissues; the colon and the ciliary epithelium, from human and mouse. The pattern of accumulation of COX-deficiency is similar in...

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PMID: 22015485
DOI: 10.1016/j.mad.2011.10.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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