Article
Mitochondrial DNA mutations in human colonic crypt stem cells.
The Journal of clinical investigation - 1 Nov 2003
Taylor Robert W, Barron Martin J, Borthwick Gillian M, Gospel Amy, Chinnery Patrick F, Samuels David C, Taylor Geoffrey A, Plusa Stefan M, Needham Stephanie J, Greaves Laura C, Kirkwood Thomas B L, Turnbull Douglass M
Abstract excerpt
The mitochondrial genome encodes 13 essential subunits of the respiratory chain and has remarkable genetics based on uniparental inheritance. Within human populations, the mitochondrial genome has a high rate of sequence divergence with multiple polymorphic variants and thus has played a major role in examining the evolutionary history of our species. In recent years it has also become apparent that pathogenic...
Read the complete abstract on PubMedTopics
- Aged
- Aged, 80 and over
- Colon
- DNA Replication
- DNA, Mitochondrial
- Electron Transport