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Article

CHEK2 mutations and HNPCC-related colorectal cancer.

International journal of cancer - 15 Jun 2010

Suchy Janina, Cybulski Cezary, Wokołorczyk Dominika, Oszurek Oleg, Górski Bohdan, Debniak Tadeusz, Jakubowska Anna, Gronwald Jacek, Huzarski Tomasz, Byrski Tomasz, Dziuba Ireneusz, Gogacz Marek, Wiśniowski Rafał, Wandzel Piotr, Banaszkiewicz Zbigniew, Kurzawski Grzegorz, Kładny Józef, Narod Steven A, Lubiński Jan

Abstract excerpt

Recently, the 1100delC variant of cell cycle checkpoint kinase 2 (CHEK2) has been reported to confer a colorectal cancer risk in hereditary non-polyposis-colorectal cancer (HNPCC) and HNPCC-related families in the Netherlands. To investigate whether CHEK2 mutations confer increased cancer risk in HNPCC and HNPCC-related families in Poland, we genotyped 463 probands from HNPCC and HNPCC-related families, and 5,496...

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Source

Identifiers

PMID: 19876921
DOI: 10.1002/ijc.25003

Genes

CHEK2
MLH1
MSH2
MSH6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CHEK2 mutations and HNPCC-related colorectal cancer.PMID 19876921Read ↗

The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population.Semantic proximity Read ↗

Germline CHEK2 mutations and colorectal cancer risk: different effects of a missense and truncating mutations?Semantic proximity Read ↗

The CHEK2 I157T variant and colorectal cancer susceptibility: a systematic review and meta-analysis.Semantic proximity Read ↗

CHEK2 1100delC is a susceptibility allele for HNPCC-related colorectal cancer.Semantic proximity Read ↗

Meta-analysis of CHEK2 1100delC variant and colorectal cancer susceptibility.Semantic proximity Read ↗

The risk of gastric cancer in carriers of CHEK2 mutations.Semantic proximity Read ↗

CHEK2 1100delC, IVS2+1G>A and I157T mutations are not present in colorectal cancer cases from Turkish population.Semantic proximity Read ↗

The effect of CHEK2 variant I157T on cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

CHEK2 I157T associates with familial and sporadic colorectal cancerSemantic proximity Read ↗

CHEK2 I157T and colorectal cancer in Bulgaria.Semantic proximity Read ↗

CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify the risk of sporadic pancreatic cancer.Semantic proximity Read ↗

The CHEK2 1100delC allele is not relevant for risk assessment in HNPCC and HBCC Spanish families.Semantic proximity Read ↗

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