Article
The CHEK2 1100delC allele is not relevant for risk assessment in HNPCC and HBCC Spanish families.
Familial cancer - 1 Jan 2005
Sánchez de Abajo Ana, de la Hoya Miguel, Godino Javier, Furió Vicente, Tosar Alicia, Pérez-Segura Pedro, Díaz-Rubio Eduardo, Caldés Trinidad
Abstract excerpt
The frame-shift mutation 1100delC in the cell-cycle-checkpoint kinase 2 gene (CHEK2) has been reported to be a low penetrance breast cancer gene in Northern European populations. However, the variant may be relevant for breast cancer risk in other populations, due to its low prevalence. Recent studies have proposed a role for the mutation in colorectal cancer, finding a strong association between the...
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