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Article

The CHEK2 I157T variant and colorectal cancer susceptibility: a systematic review and meta-analysis.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012

Liu Chuan, Wang Qing-Shui, Wang Ya-Jie

Abstract excerpt

BACKGROUND: The cell cycle checkpoint kinase 2 (CHEK2) gene I157T variant may be associated with an increased risk of colorectal cancer, but it is unclear whether the evidence is sufficient to recommend testing for the mutation in clinical practice. MATERIALS AND METHODS: We systematically searched PubMed, EMBASES, Elsevier and Springer for relevant articles before Apr 2012. Summary odds ratios (ORs) and 95%...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22901170
DOI: 10.7314/apjcp.2012.13.5.2051

Genes

CHEK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CHEK2 I157T variant and colorectal cancer susceptibility: a systematic review and meta-analysis.PMID 22901170Read ↗

The effect of CHEK2 variant I157T on cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

CHEK2 I157T associates with familial and sporadic colorectal cancerSemantic proximity Read ↗

The CHEK2 I157T variant and breast cancer susceptibility: a systematic review and meta-analysis.Semantic proximity Read ↗

The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population.Semantic proximity Read ↗

Meta-analysis of CHEK2 1100delC variant and colorectal cancer susceptibility.Semantic proximity Read ↗

CHEK2 1100delC, IVS2+1G>A and I157T mutations are not present in colorectal cancer cases from Turkish population.Semantic proximity Read ↗

CHEK2 I157T and colorectal cancer in Bulgaria.Semantic proximity Read ↗

Germline CHEK2 mutations and colorectal cancer risk: different effects of a missense and truncating mutations?Semantic proximity Read ↗

CHEK2 I157T and endometrial cancer.Semantic proximity Read ↗

CHEK2 variants predispose to benign, borderline and low-grade invasive ovarian tumors.Semantic proximity Read ↗

A Comparison between CHEK2*1100delC/I157T Mutation Carrier and Noncarrier Breast Cancer Patients: A Clinicopathological Analysis.Semantic proximity Read ↗

CHEK2 mutations and HNPCC-related colorectal cancer.Semantic proximity Read ↗

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