Article
Germline CHEK2 mutations and colorectal cancer risk: different effects of a missense and truncating mutations?
European journal of human genetics : EJHG - 1 Feb 2007
Cybulski Cezary, Wokołorczyk Dominika, Kładny Józef, Kurzawski Grzegorz, Kurzwaski Grzegorz, Suchy Joanna, Grabowska Ewa, Gronwald Jacek, Huzarski Tomasz, Byrski Tomasz, Górski Bohdan, D Ecedil Bniak Tadeusz, Narod Steven A, Lubiński Jan
Abstract excerpt
Germline mutations in cell cycle checkpoint kinase 2 (CHEK2) have been associated with a range of cancer types, in particular of the breast and prostate. Protein-truncating mutations in CHEK2 have been reported to confer higher risks of cancer of the breast and the prostate than the missense I157T variant. In order to estimate the risks of colorectal cancer associated with truncating and missense CHEK2 mutations,...
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