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Article

CHEK2 I157T associates with familial and sporadic colorectal cancer

30 Jun 2006

Abstract excerpt

BACKGROUND: Recently, a functionally defective CHEK2 variant I157T has been proposed to associate with an increased risk of several types of cancer. We investigated the CHEK2 I157T variant for colorectal cancer (CRC) predisposition in a large population based study including a significant number of familial CRC cases. METHODS: We screened the CHEK2 I157T variant in a population based series of 1042 Finnish CRC...

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Identifiers

PMID: 16816021
DOI: 10.1136/jmg.2005.038331

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