Article
hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction.
PloS one - 1 Jan 2018
Guha Manti, Srinivasan Satish, Johnson F Bradley, Ruthel Gordon, Guja Kip, Garcia-Diaz Miguel, Kaufman Brett A, Glineburg M Rebecca, Fang JiKang, Nakagawa Hiroshi, Basha Jeelan, Kundu Tapas, Avadhani Narayan G
Abstract excerpt
Telomeres protect against chromosomal damage. Accelerated telomere loss has been associated with premature aging syndromes such as Werner's syndrome and Dyskeratosis Congenita, while, progressive telomere loss activates a DNA damage response leading to chromosomal instability, typically observed in cancer cells and senescent cells. Therefore, identifying mechanisms of telomere length maintenance is critical for...
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