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Article

TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast.

PloS one - 1 Jan 2018

Wanat Jennifer J, Logsdon Glennis A, Driskill Jordan H, Deng Zhong, Lieberman Paul M, Johnson F Brad

Abstract excerpt

The events underlying senescence induced by critical telomere shortening are not fully understood. Here we provide evidence that TERRA, a non-coding RNA transcribed from subtelomeres, contributes to senescence in yeast lacking telomerase (tlc1Δ). Levels of TERRA expressed from multiple telomere ends appear elevated at senescence, and expression of an artificial RNA complementary to TERRA (anti-TERRA) binds TERRA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29649255
DOI: 10.1371/journal.pone.0195698
PMCID: PMC5896980

Genes

EXO1
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast.PMID 29649255Read ↗

Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase.Semantic proximity Read ↗

TERRA increases at short telomeres in yeast survivors and regulates survivor associated senescence (SAS)Semantic proximity Read ↗

TERRA long noncoding RNA: At the interphase of telomere damage, rescue and signalingSemantic proximity Read ↗

Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read ↗

TERRA stability is regulated by RALY and polyadenylation in a telomere-specific mannerSemantic proximity Read ↗

Functional characterization of the TERRA transcriptome at damaged telomeresSemantic proximity Read ↗

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short TelomeresSemantic proximity Read ↗

The Emerging Roles of TERRA in Telomere Maintenance and Genome StabilitySemantic proximity Read ↗

Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast.Semantic proximity Read ↗

YTHDC1 drives senescence evasion in ovarian cancer through m6A-mediated TERT StabilizationSemantic proximity Read ↗

EXO1 plays a role in generating type I and type II survivors in budding yeast.Semantic proximity Read ↗

TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome EndsSemantic proximity Read ↗

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