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Article

Impaired osteoblast function in GPRC6A null mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2010

Pi Min, Zhang Lishu, Lei Shu-Feng, Huang Min-Zhao, Zhu Wenyu, Zhang Jianghong, Shen Hui, Deng Hong-Wen, Quarles L Darryl

Abstract excerpt

GPRC6A is a widely expressed orphan G protein-coupled receptor that senses extracellular amino acids, osteocalcin, and divalent cations in vitro. GPRC6A null (GPRC6A(-/-)) mice exhibit multiple metabolic abnormalities including osteopenia. To investigate whether the osseous abnormalities are a direct function of GPRC6A in osteoblasts, we examined the function of primary osteoblasts and bone marrow stromal cell...

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Identifiers

PMID: 19874200
DOI: 10.1359/jbmr.091037
PMCID: PMC3153369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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