Article
GPR30 deficiency causes increased bone mass, mineralization, and growth plate proliferative activity in male mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2011
Ford Jeffery, Hajibeigi Asghar, Long Michael, Hahner Lisa, Gore Crystal, Hsieh Jer-Tseng, Clegg Deborah, Zerwekh Joseph, Oz Orhan K
Abstract excerpt
Estrogen regulation of the male skeleton was first clearly demonstrated in patients with aromatase deficiency or a mutation in the ERα gene. Estrogen action on the skeleton is thought to occur mainly through the action of the nuclear receptors ERα and ERβ. Recently, in vitro studies have shown th...
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