Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic characterization of Grm1crv4 mice reveals a functional role for the type 1 metabotropic glutamate receptor in bone mineralization.

Bone - 1 Jan 2017

Musante Ilaria, Mattinzoli Deborah, Otescu Lavinia Alexandra, Bossi Simone, Ikehata Masami, Gentili Chiara, Cangemi Giuliana, Gatti Cinzia, Emionite Laura, Messa Piergiorgio, Ravazzolo Roberto, Rastaldi Maria Pia, Riccardi Daniela, Puliti Aldamaria

Abstract excerpt

Recent increasing evidence supports a role for neuronal type signaling in bone. Specifically glutamate receptors have been found in cells responsible for bone remodeling, namely the osteoblasts and the osteoclasts. While most studies have focused on ionotropic glutamate receptors, the relevance of the metabotropic glutamate signaling in bone is poorly understood. Specifically type 1 metabotropic glutamate (mGlu1)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Size
Share to Bone Density

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Development

Share to Calcification, Physiologic

Share to Organ Size

Share to Osteoblasts

Share to Osteoclasts

Share to Receptors, Metabotropic Glutamate

Source

Identifiers

PMID: 27989650
DOI: 10.1016/j.bone.2016.10.025

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic characterization of Grm1crv4 mice reveals a functional role for the type 1 metabotropic glutamate receptor in bone mineralization.PMID 27989650Read ↗

Albuminuria and glomerular damage in mice lacking the metabotropic glutamate receptor 1.Semantic proximity Read ↗

Compensatory molecular and functional mechanisms in nervous system of the Grm1(crv4) mouse lacking the mGlu1 receptor: a model for motor coordination deficits.Semantic proximity Read ↗

No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions.Semantic proximity Read ↗

Impaired osteoblast function in GPRC6A null mice.Semantic proximity Read ↗

GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome.Semantic proximity Read ↗

Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect.Semantic proximity Read ↗

Genetic inactivation of mGlu5 receptor improves motor coordination in the Grm1crv4 mouse model of SCAR13 ataxia.Semantic proximity Read ↗

Rickets in cation-sensing receptor-deficient mice: an unexpected skeletal phenotype.Semantic proximity Read ↗

Increased bone density in mice lacking the proton receptor OGR1.Semantic proximity Read ↗

crv4, a mouse model for human ataxia associated with kyphoscoliosis caused by an mRNA splicing mutation of the metabotropic glutamate receptor 1 (Grm1).Semantic proximity Read ↗

Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum.Semantic proximity Read ↗

Regulation of body length and bone mass by Gpr126/Adgrg6.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.