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Article

Increased bone density in mice lacking the proton receptor OGR1.

Kidney international - 1 Mar 2016

Krieger Nancy S, Yao Zhenqiang, Kyker-Snowman Kelly, Kim Min Ho, Boyce Brendan F, Bushinsky David A

Abstract excerpt

Chronic metabolic acidosis stimulates cell-mediated calcium efflux from bone through osteoblastic prostaglandin E2-induced stimulation of receptor activator of NF-kB ligand leading to increased osteoclastic bone resorption. Osteoblasts express the proton-sensing G-protein-coupled receptor OGR1, which activates inositol phosphate-mediated intracellular calcium. Proton-induced osteoblastic intracellular calcium...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26880453
DOI: 10.1016/j.kint.2015.12.020
PMCID: PMC4757816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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